SAMe is a naturally occurring metabolite found in the human body as well as in plant and animal foods. SAMe is naturally synthesized in humans from the amino acid methionine in the presence of the cofactors B12 and folate.

SAMe is the most active of all methyl donors and has been compared to ATP in its importance for the body.
SAMe is involved in the synthesis of:
  • Neurotransmitters
  • The hormone melatonin
  • Phospholipids
  • Polyamines, which control cellular growth
It is also the source of methyl groups inside the nucleus for DNA methylation which controls gene expression and masking of genetic damage.
Even if the body is producing normal or average levels of SAMe, certain physiological states create an increased demand for it, such as: aging, dietary deficiency, inflammatory states, emotional/physical stress or genetic polymorphysms.
Sub-optimal levels of SAMe in some individuals may be due to insufficient amounts of the precursor amino acid methionine (vegetarianism or poor protein intake). Age-related decline in enzyme efficiencies throughout the body can be improved by increasing the supply of enzyme cofactors such as SAMe, B-vitamins and magnesium.
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