- Because of the potential for side effects and interactions with medications, you should take dietary supplements only under the supervision of a knowledgeable health care provider.
Side effects may include dry mouth, nausea, gas, diarrhea, headache, anxiety, a feeling of elation, restlessness, and insomnia. Sweating, dizziness, and palpitations have also been reported. For this reason, you should not take SAMe at night.
Large doses of SAMe may cause mania (abnormally elevated mood). Start at a low dose and gradually increase it. DO NOT exceed recommended doses. Pregnant and breastfeeding women should not take SAMe.
People with bipolar disorder (manic depression) should not take SAMe since it may worsen manic episodes.
SAMe should not be combined with other antidepressants without first consulting your doctor.
People taking SAMe may want to take a multivitamin that contains folic acid and vitamins B12 and B6.