Starting with a low dose (for example, 200 mg per day) and increasing slowly helps avoid stomach upset.
Small studies suggest that oral supplementation with SAMe is not well absorbed by the body. Clinicians recommend taking oral SAMe with vitamin B12, folic acid, methionine, and trimethylglycine to enhance absorption.
SAMe should never be given to a child without your doctor's supervision.
For Alcoholic liver disease: 600 to 1,200 mg per day by mouth in divided doses for 6 months enhances liver function.
For liver disease, a qualified health care provider should supervise administration of SAMe.